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Aging and Health
August5, 2024
John C.Newman,MD, PhD1,2; Iman M.Al-Naggar,PhD3,4; George A.Kuchel,MD3
Author Affiliations Article Information
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1Department of Medicine, University of California, San Francisco
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2Buck Institute for Research on Aging, Novato, California
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3UConn Center on Aging, UConn Health, Farmington, Connecticut
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4Department of Cell Biology, UConn Health, Farmington, Connecticut
JAMA Intern Med. Published online August 5, 2024. doi:10.1001/jamainternmed.2024.2534
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The founding mission of the National Institute on Aging (NIA) was visionary and broad—from understanding the basic biology of aging to enhancing care, quality, and outcomes for older adults. Their investment and vision have led to innovative research in biological sciences exemplified by identification of about a dozen cellular and molecular mechanisms that drive both aging and several chronic diseases.1 These advances have given rise to the geroscience hypothesis and the field of geroscience. The geroscience hypothesis states that interventions modifying biological mechanisms of aging (gerotherapeutics) might prevent, delay, or alleviate several age-related diseases simultaneously, lengthening the lifespan and, more importantly, increasing the health span, defined as the length of life without illness or disability.1,2 Thus, geroscience focuses on translational applications that hold the potential to alter the course of aging and chronic diseases (Box).
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Newman JC, Al-Naggar IM, Kuchel GA. Role of the National Institute on Aging in Transforming Aging Research Through Geroscience and Gerotherapeutics—50 Years of Innovation. JAMA Intern Med. Published online August 05, 2024. doi:10.1001/jamainternmed.2024.2534
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